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ADVANCING BREAKTHROUGH THERAPEUTICS FOR CNS DISORDERS

DISCOVER THE FUTURE OF CNS THERAPEUTICS

We Are Visionaries

Blending innovation, responsibility, and accessibility to deliver transformative therapeutic solutions. 

Our vision at EQUULUS Therapeutics is to turn the promise of psychedelics into real-world therapeutics that transform patients' lives and set a new standard in neuroscience healthcare.

Doctor analyzing brain scans
Image by Jose Antonio Rodriguez Davia

Research & Pipeline

EQUULUS takes a transdiagnostic approach to developing CNS therapeutics, moving beyond traditional diagnostic boundaries.

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1

EQL-101

Substance Use Disorder

  • EQL-101 is being designed as the ultimate-generation Ibogaine analog for the treatment of SUD’s and PTSD. By decoupling hallucinatory pathways from neuroplasticity mechanisms and mitigating cardiotoxicity, Equulus is advancing EQL-101 through IND enabling studies to achieve first in human dosing by Q4 2026. 

2

MDMA Analog

PTSD

  • Our MDMA-inspired, discovery stage, small molecule is being designed to preserve pro-extinction and pro-social neuroplasticity benefits for the treatment of PTSD while minimizing stimulant load, hyperthermia risk, and abuse liability. Through structure–activity optimization within our 5-HT releaser platform, we aim to decouple therapeutic signaling from unwanted effects for a cardio-safer, non-hallucinogenic profile. Next Milestone: Candidate Selection.

3

Fenfluramine Analog

Obesity & Seizure Disorders

  • Our next-generation fenfluramine-class agent is being designed to retain seizure-modifying and appetite-regulating efficacy while reducing historical cardiovascular liabilities associated with legacy fenfluramine. Through structure–activity optimization within our 5-HT releaser platform, the medicinal chemistry is focused on selective serotonergic modulation and improved developability to support use in seizure disorders such as epilepsy and obesity. Next Milestone: Candidate Selection

What We Stand For

Innovation, Health, Humanity.

At EQUULUS Therapeutics, our vision is to turn the promise of psychedelic-inspired science into safe, evidence-based medicines with clear pathways to regulatory approval and payer adoption, delivered at scale so every patient who needs them can access and afford them.

Bob Discordia
CEO and Co-Founder of 
Equulus

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Dr. Robert Discordia, Co-Founder, President & CEO of Equulus Therapeutics, brings 30+ years of leadership across the pharmaceutical and biotech industries. An expert in end-to-end drug development and CMC, he has advanced programs from preclinical through clinical development and commercialization across multiple modalities and therapeutic areas. He is recognized for building high-performing teams, optimizing global development and supply networks, and translating innovation into safe, effective medicines.

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Robert Discordia, PhD

Co-Founder, President &

 Chief Executive Officer

Dr. Peter Hendricks, Co-Founder, Director, and Chief Advisor on Clinical Psychology at Equulus Therapeutics, is the Heersink Endowed Professor in the Department of Psychiatry and Behavioral Neurobiology at the University of Alabama at Birmingham. A clinical psychologist with deep expertise in CNS disorders and patient-centered outcomes, he has designed and led numerous clinical trials of psychedelic-assisted therapies. Bridging academic rigor with industry execution, he guides Equulus’ clinical psychology strategy to translate evidence into scalable, clinically meaningful therapeutics.

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Peter Hendricks, PhD

Co-Founder & Director

 Clinical Psychology 

Dr. Bruce Blough, Co-Founder, Director on the Board of Directors, and Chief Advisor on Medicinal Chemistry at Equulus, is a veteran medicinal chemist focused on CNS therapeutics and translational drug design. Creator of Equulus’ Serotonin Releaser Technology—developed at Research Triangle Institute (RTI)—he advances novel, neurotherapeutics from hit discovery through lead optimization and IND-enabling studies. He brings decades of experience in SAR, scaffold engineering, and IP strategy, guiding portfolio chemistry, external collaborations, and CMC interfaces to deliver clinically viable candidates.

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Bruce Blough, PhD

Co-Founder & Director

Medicinal Chemistry 

Co-Founder and Director on the Board of Equulus, Dr. Murnane is Associate Professor of Pharmacology, Toxicology & Neuroscience and of Psychiatry at LSU Health Shreveport  and serves as Director of Basic Science Research for the Louisiana Addiction Research Center. A specialist in neuropharmacology and neurotoxicology, his lab investigates addiction and stimulant-induced brain injury using behavioral pharmacology, receptor systems, neurochemistry, and neuroimaging. At Equulus, he guides preclinical model strategy, safety assessment, and mechanism-based decision thresholds that de-risk assets and accelerate IND-enabling progress.

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Kevin Murnane, PhD

Co-Founder & Director Neuropharmacology & Neurotoxicology

Drew Mouton, Co-Founder, Director on the Board of Directors, and Chief Business Officer (CBO) of Equulus Therapeutics, advises on corporate strategy, business development, and capital formation.
A seasoned operator, he has driven partnering, licensing, and alliance management; built portfolio and go-to-market strategies; and structured both dilutive and non-dilutive financings to advance clinical programs. At Equulus, he advises on investor relations and strategic collaborations that accelerate our CNS pipeline and build durable enterprise value.

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Drew Mouton

Chief Business Officer

Meet the Team

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Meet the Advisory Board

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Dr. Richard Shelton

University of Alabama at Birmingham

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Dr. Bruce Car

Biohaven Pharmaceuticals, CSO

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Dr. John Renger

Principal, Neurtuitive, 

Former CSO, Cerevel

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Pamela Perry

Former SVP, Cerevel Therapeutics

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Dr. Neal Naito

CEO, MVK Pharmaceuticals

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Dr. Andrew Riley

Assistant Professor of Pharmaceutical Sciences Medicinal Chemistry & Pharmacognosy at the University of Illinois Chicago

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Angela Terhune Hargrove

Co-Founder, CSO at First Coast Research Center

Equulus Investor Presentation

Equulus Therapeutics is advancing breakthrough therapeutics for central nervous system (CNS) disorders using a transdiagnostic strategy rooted in disease-driving physiology—guided by an experienced neuroscience team and developed with strategic partners. Open the deck to explore our science, programs, and milestones.

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Equulus in Numbers

OUR PARTNERS

3

Pipeline Assets

4

Research Programs

6

Patents

Petri Dish Experiment

Media

After the Billion-Dollar Psychedelic Bet: Who’s Next for Big Pharma?

Microdose

NIH Awards $2.4 M to X-Disciplinary Team of Researchers to Study Psychedelics for MA Addiction

Medical College of Wisconsin

Rethinking Mental Health: How Emerging Therapies Are Changing the Game

Newsweek

The Best Advice I Ever Got: On The Job

Clinical Leader

Innovating CNS Disorder Treatment: EQUULUS and the Revolutionary Approach with Analog Ibogaine

Microdose

EQUULUS Therapeutics Emerges from Stealth

Psychedelic Alpha

Small but mighty: The role of small-molecule drugs in disease treatment

LaBiotech

Bucking Convention: How Analog Ibogaine Could Help Conquer CNS Disorders

Drug Discovery Online

Press

There’s a New Kid in Town, Changing the Face of Genetic Engineering.


March 2035

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